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StemXCell™ Technology: Targeted Benefits for Skincare and Haircare

StemXCell™ Technology is PrimeGen's proprietary technology designed to precondition stem cells under specialized growth conditions that enhance their ability to deliver targeted benefits for skincare and haircare applications. While stem cells naturally produce bioactive factors that support skin rejuvenation—their full potential may not be fully realized under standard laboratory conditions. This differentiates Étrive™ Aesthetic Solutions from traditional exosomes products in the market and qualifies Etrive series as next-gen extracellular vesicles (EVs) products.

Benefits of Stem Cells Grown Based On StemXCell technology

By customizing the cellular environment to closely replicate conditions that promote healthy skin and hair, StemXCell™ technology enables stem cells to produce a highly refined profile of bioactive molecules. These molecules are delivered via extracellular vesicles—tiny, naturally occurring carriers that stem cells use for skin cell-to-cell communication. The active ingredients are preserved in Étrive™ Aesthetic Solutions, remaining potent in their lyophilized form and after reconstitution, to effectively enhance a youthful skin appearance.

StemXCell Technology Backed by Science

Compared to conventional mesenchymal stem cells (MSCs), those cultured and expanded using StemXCell™ Technology have demonstrated significant advantages in both in vitro and preclinical studies. Laboratory data show that MSCs produced via StemXCell™ generate 2- to 5-fold differences in the levels of skincare-relevant cytokines and chemokines compared to conventionally grown MSCs. Specifically, seven cytokines and chemokines associated with skin rejuvenation are significantly increased, while five inhibitory ones are notably reduced.

Published preclinical studies further indicate that these MSCs markedly reduce inflammation and immune rejection responses. Collectively, these findings support that MSCs preconditioned with StemXCell™ Technology produce highly potent extracellular vesicles (EVs), offering substantial benefits for skin and hair rejuvenation.

Watch videos for exosomes and extracellular vesicles for skincare

Stem cells are special cells in the body that can self-renew and become other specialized cells. They are used for regenerative medicine and cosmetics.

Get to know Étrive Aesthetic Solutions

Our brochure provides detailed information on

Étrive Aesthetic Solutions products and their use for skin and hair care.

What are exosomes or extracellular vesicles (EVs)?

Exosomes or extracellular vesicles (EVs) are small vesicles secreted from cells to communicate with other cells due to the rich bioactive molecules they carry.

Have more questions?

The frequently asked questions helps you understand better on the safety, manufacturing and use of the DERMA-activEXO products.

We post regularly on extracellular vesicles (EVs) on skincare in the format of blog.